183308-64-7Relevant academic research and scientific papers
The first total synthesis of 15-epi-annonin I
Woehrle, Ingo,Classen, Arno,Peterek, Marcus,Scharf, Hans-Dieter
, p. 7001 - 7004 (1996)
The first total synthesis of the 15-epimer 1b of the naturally occurring acetogenin annonin I 1a is described. All stereogenic centres in the bis-THF subunit are controlled via successive Sharpless asymmetric epoxidations (AE). Alkyl side chains were attached directly to the core using alkyne-epoxide couplings.
