183311-35-5Relevant articles and documents
Mono-aroylation of 2,3-, 3,4-diaminopyridine and 4,5-diaminopyrimidine and synthesis of putative inotrope/&β-adrenoceptor antagonists
Barraclough, Paul,Collard, David,Gillam, Janet,King, W. Richard,Smith, Steven
, p. 2316 - 2335 (2007/10/03)
Mono-aroylation of 2,3-diaminopyridine with the oxazolidinone benzoyl chloride (4) occurs at N-3. 3,4-Diaminopyridine undergoes aroylation at N-4.Tert-butoxylation occurs with the same regiospecificity and subsequent aroylation-deprotection affords the isomeric mono-aroyl derivatives. 4,5-diaminopyrimidine undergoes N-4 aroylation at room temperature but at 120 deg C aroylation at N-5 occurs.Monoamides 6, 8, and 10 were converted to putative inotropic/β-adrenergic antagonist compounds 1-3.