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183320-04-9

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183320-04-9 Usage

Uses

6-O-Desmethoxyethyl-6-O-chloroethyl Erlotinib hydrochloride is a derivative of Erlotinib (E625000), an epidermal growth factor receptor inhibitor and tyrosine kinase inhibitor that is used to treat patients with lung cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 183320-04-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,3,2 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 183320-04:
(8*1)+(7*8)+(6*3)+(5*3)+(4*2)+(3*0)+(2*0)+(1*4)=109
109 % 10 = 9
So 183320-04-9 is a valid CAS Registry Number.

183320-04-9Downstream Products

183320-04-9Relevant articles and documents

Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazine

Zhang, Gengzhen,Zha, Linlin

, p. 2303 - 2309 (2013/07/26)

Optimized synthesis and purification of erlotinib hydrochloride (N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazoline-4-amine hydrochloride) were studied. Highly polar piperazine was used in a nucleophilic substitution reaction with the chlorinated intermediate byproduct N-(3-ethynylphenyl)-6(2- chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. As a result, N-(3-ethynylphenyl)-6(2-chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride was completely transformed to N-(3-ethynylphenyl)-6(2- piperzinoethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. The polarity of N-(3-ethynylphenyl)-6(2-piperzinoethoxy)-7-(2-methoxyethoxy) quinazolin-4-amine hydrochloride was changed, and its molecule was enlarged. It was easy to remove this larger, more polar, compound by recrystallization. Highly pure erlotinib hydrochloride was obtained with low impurity content (99.9 %.

ALKYNYL AND AZIDO-SUBSTITUTED 4-ANILINOQUINAZOLINES

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, (2008/06/13)

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