183320-51-6

Basic information

• Product Name: OSI-420
• Synonyms: 2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol hydrochloride;Ethanol, 2-[[4-[(3-ethynylphenyl)aMino]-7-(2-Methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride;OSI-420 (DesMethyl Erlotinib,CP-473420);CP-473420;DesMethyl Erlotinib;OSI-420 hydrochloride;OSI-420 (DesMethyl Erlotinib);Erlotinib O-DesMethyl Metabolite IsoMer (M14) HCl
• CAS NO: 183320-51-6
• Molecular Formula: C21H22ClN3O4
• Molecular Weight: 415.87008
• EINECS: 200-258-5
• Product Categories: Inhibitors
• Mol File: 183320-51-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: OSI-420(CAS DataBase Reference)
• NIST Chemistry Reference: OSI-420(183320-51-6)
• EPA Substance Registry System: OSI-420(183320-51-6)

Safety Data

• Hazardous Substances Data: 183320-51-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 183320-51-6 differently. You can refer to the following data:
1. OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
2. OSI 420 can be used in biological study of effects of cytochrome P 450 3A on pharmacokinetic interaction between erlotinib and docetaxel in rats.