18334-96-8Relevant academic research and scientific papers
8-aminoquinoline-melatonin complex and pharmaceutical composition thereof
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Paragraph 0094; 0104, (2017/02/17)
The invention relates to synthesized 8-aminoquinoline-melatonin complex, in particular to an 8-aminoquinoline-melatonin complex and a pharmaceutical composition thereof. The 8-aminoquinoline-melatonin complex is of a structure as shown in the structural formula (I); on one hand, the compounds can selectively chelate copper ions; on the other hand, the compounds play a role in well protecting nerves and nerve cells to improve AD (Alzheimer's disease) symptoms. The invention further relates to a pharmaceutical composition or nerve cell protective agent comprising the complex or pharmaceutically acceptable salt thereof. The invention further relates to pharmaceutical application of the complex.
SMALL MOLECULE INDUCERS OF GDNF AS POTENTIAL NEW THERAPEUTICS FOR NEUROPSYCHIATRIC DISORDERS
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Page/Page column 101; 102, (2013/03/26)
The invention provides a compound having the structure (I), wherein A is a substituted or unsubstituted ring; Z is present or absent and when present is (II), wherein n is 0, 1, 2, 3, or 4; Y is -(CR11R12)-, -NH(CR11R12)- or -O(CR11R12)- wherein R11 and R12 are each hydrogen or combine to form a carbonyl; and wherein R1 to R10 are herein as described.
NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS
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, (2012/09/10)
The present invention relates to pyrazole and imidazole derivatives of formula (I) wherein U, V, L, X, Y, R1, (R2)n and (R3)m and ring A are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.
Indole, indazole and benzisoxazole compounds
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, (2008/06/13)
Compound of formula (I): STR1 in which: R1 represents hydrogen, halogen, alkyl, alkoxy, trihalomethyl or hydroxyl, R2 represents hydrogen, alkyl or phenyl which is optionally substituted, STR2 or alternatively STR3 represents --O--N=, 1≤n≤6, STR4 represents any one of the groups defined in the description, its isomers and its addition salts with a pharmaceutically acceptable acid or base, a medicinal products containing the same are useful in the treatment of schizophrenia.
Total syntheses of 10-methoxydihydrocorynantheol and 10-methoxycorynantheidol
Miettinen,Jokela,Lounasmaa
, p. 42 - 45 (2007/10/03)
10-Methoxydihydrocorynantheol and 10-methoxycorynantheidol were synthesized from 5-methoxytryptophol and 3-acetylpyridine. 13C-NMR data of the prepared compounds and their synthetic intermediates are given.
9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones
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, (2008/06/13)
Compounds useful in the prevention and/or treatment of hypertension, congestive heart failure, arrhythmia, migraine, vasospastic disorders, and asthma are represented by the formula STR1 wherein: R, R1, R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; and R5 and R6 are independently hydrogen, lower alkyl of one to four carbon atoms or lower alkoxy of one to four carbon atoms; and the pharmaceutically acceptable acid addition salts thereof.
Indolylalkylpiperidines
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, (2008/06/13)
1-(Indolyl-3-alkyl)-3 or 4-(ureido or guanidino)-piperidines, e.g. those of the formula STR1 R= H; alkyl; free, etherified or esterified OH or SH; CF3, NO2 or NH2 m= 1-4; n= 2 or 3; X= O, S or NH acyl derivatives and salts thereof are antihypertensive agents.
