183379-53-5Relevant academic research and scientific papers
Synthesis of peptides containing oxo amino acids and their crystallographic analysis
Kalita, Mrinal,Archana, Archana,Dimri, Astha,Vasudev, Prema G.,Ramapanicker, Ramesh
, (2019)
An isolated uncharged hydrogen bond acceptor such as the carbonyl functionality of an aldehyde or a keto group is absent in natural amino acids. Although glutamine and asparagine are known to hydrogen bond through the amide carbonyl group in their side ch
Enantioselective CpxRhIII-Catalyzed Carboaminations of Acrylates
Cramer, Nicolai,Duchemin, Coralie
supporting information, p. 14129 - 14133 (2020/06/17)
Enantioselective carboaminations of olefins constitute an attractive strategy for a rapid increase in molecular complexity from readily available starting materials. Reported here is an intermolecular asymmetric carboamination of acrylates using rhodium(III)-catalyzed alkenyl C?H activations of N-enoxysuccinimides to generate the nitrogen and carbon portion for the transfer. A rhodium complex equipped with a tailored bulky trisubstituted chiral Cpx ligand ensures carboamination chemoselectivity as well high levels of enantioinduction. The transformation operates under mild reaction conditions at ambient temperatures and provides access to a variety of α-amino esters in good yields and excellent enantiomeric ratios of >99.5:0.5.
PROCESS FOR PRODUCTION OF NONNATURAL AMINO ACIDS AND INTERMEDIATES THEREFOR
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Page/Page column 13, (2010/11/25)
A process for the preparation of a nonnatural amino acid represented by the following formula (C): which is characterized by reacting a compound represented by the following formula (A1), a compound represented by the following formula (A2) and a compoun
