183380-25-8Relevant academic research and scientific papers
Low-valent titanium mediated reductive cleavage of O/N-trityl bonds via free radical pathway
Rele, Shyam,Nayak, Sandip K.
, p. 3533 - 3540 (2002)
Low-valent titanium mediated cleavage of trityl-O/N bonds in trityl ethers/amines via electron transfer process is reported. Chemoselective deprotection of trityl ethers in preference to benzyl ethers is achieved. The ease of cleavage of protected alcohols and amines is in the order O-allyl > O-trityl > O-benzyl; N-trityl > O-trityl bonds.
INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS
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Paragraph 0409; 0412, (2018/04/21)
The present disclosure relates to compounds and a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing the compounds, and processes for their preparation. The disclosure also relates to the use of the compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.
