183383-55-3Relevant academic research and scientific papers
Prostaglandin E2-bisphosphonate conjugates: Potential agents for treatment of osteoporosis
Gil, Laurent,Han, Yongxin,Opas, Evan E.,Rodan, Gideon A.,Ruel, Rejean,Seedor, J. Gregory,Tyler, Peter C.,Young, Robert N.
, p. 901 - 919 (1999)
Conjugates of bisphosphonates (potential bone resorption inhibitors) and prostaglandin E2 (a bone formation enhancer) were prepared and evaluated for their ability to bind to bone and to liberate, enzymatically, free PGE2. The conjugate 3, an amide at C-1 of PGE2 proved to be too stable in vivo while conjugate 6, a thioester, was too labile. Several PGE2, C-15 ester-linked conjugates (18, 23, 24 and 31) were prepared and conjugate 23 was found to bind effectively to bone in vitro and in vivo and to liberate PGE2 at an acceptable rate. A 4-week study in a rat model of osteoporosis showed that 23 was better tolerated and more effective as a bone growth stimulant than daily maximum tolerated doses of free PGE2. Copyright (C) 1999 Elsevier Science Ltd.
Synthesis of new potential chelating agents: Catechol-bisphosphonate conjugates for metal intoxication therapy
Xu, Guangyu,Yang, Chunhao,Liu, Bo,Wu, Xihan,Xie, Yuyuan
, p. 251 - 257 (2007/10/03)
In a quest for better chelating therapy drugs for the treatment of intoxication by Fe, Al, or actinides, three new series of bisphosphonates conjugated with catechol were synthesized.
