18341-10-1

Basic information

• Product Name: 4-(1-phenylpropan-2-yl)morpholine
• Synonyms: 4-(1-phenylpropan-2-yl)morpholine
• CAS NO: 18341-10-1
• Molecular Weight: 205.3
• Mol File: 18341-10-1.mol

Chemical Properties

• CAS DataBase Reference: 4-(1-phenylpropan-2-yl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-phenylpropan-2-yl)morpholine(18341-10-1)
• EPA Substance Registry System: 4-(1-phenylpropan-2-yl)morpholine(18341-10-1)

Safety Data

• Hazardous Substances Data: 18341-10-1(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 300-57-2 allylbenzene 
• 698-87-3 3-phenyl-2-propanol 
• 673-32-5 1-Phenylprop-1-yne 
• 873-66-5 1-propenylbenzene 

Relevant articles and documents

Synthesis of β-phenylethylamines from styrene derivatives

β-Phenylethylamines are prepared from the styrene derivatives; 4,4- dimethyl-2-(2-vinylphenyl)-2-oxazoline, 2-(3-methoxy-2-vinylpnenyl)-4,4- dimethyl-2-oxazoline, 2-vinylbenzoic acid, styrene, β-methylstyrene, and α- methylstyrene.

Achieving Aliphatic Amine Addition to Arylalkynes via the Lewis Acid Assisted Triazole-Gold (TA-Au) Catalyst System

Transition metal catalyzed intermolecular hydroamination of the arylalkynes with aliphatic amine is generally problematic due to the good coordination between amine and metal cation. With the combination of 1,2,3-triazole coordinated gold(I) catalyst (TA-Au) and Zn(OTf)2 cocatalyst, this challenging transformation was achieved with good to excellent yields and regioselectivity. Compared to previously reported methods, this approach offered an alternative catalyst system to achieve this fundamental chemical transformation with high efficiency and practical conditions.

Ruthenium-catalyzed /V-alkylation of amines and sulfonamides using borrowing hydrogen methodology

The alkylation of amines by alcohols has been achieved using 0.5 mol percent [Ru(p-cymene)CI2]2 with the bidentate phosphines dppf or DPEphos as the catalyst. Primary amines have been converted into secondary amines, and secondary amines into tertiary amines, including the syntheses of Piribedil, Tripelennamine, and Chlorpheniramine. A/-Heterocyclization reactions of primary amines are reported, as well as alkylation reactions of primary sulfonamides. Secondary alcohols requiremore forcing conditions than primary alcohols but are still effective a lkylating agents in the presence of this catalyst.

Base-catalyzed amination of olefins: An example of an environmentally friendly synthesis of amines

The base-catalyzed amination of aromatic olefins is described as an environmentally friendly synthesis of various β-arylethylamines. Primary and secondary aliphatic amines as well as aromatic amines react with styrene derivatives to give the corresponding β-arylethylamines in high yield up to 99%. While aliphatic amines react with styrenes in the presence of n-BuLi as the pre-catalyst, anilines can be olefinated using KOtBu as the catalyst.

A base-catalyzed domino-isomerization-hydroamination reaction - A new synthetic route to amphetamines

An efficient synthesis of pharmaceutically interesting amphetamines by a base-catalyzed domino-isomerization- hydroamination reaction is presented. Starting from allylbenzene and various primary or secondary amines, the basic structural pattern of amphetamines is synthesized directly in yields of up to 91% in the presence of catalytic amounts of n-butyllithium. (C) 2000 Elsevier Science Ltd.