183428-17-3Relevant academic research and scientific papers
Artificial nucleosides possessing metal binding sites at the 3′- and 5′-positions of the deoxyribose moieties
Chiba, Jun-ya,Tanaka, Kentaro,Ohshiro, Yukinori,Miyake, Ryosuke,Hiraoka, Shuichi,Shiro, Motoo,Shionoya, Mitsuhiko
, p. 331 - 338 (2007/10/03)
This paper describes a convenient synthetic procedure for nucleoside mimics, 1-6, in which the 3′,5′-hydroxy groups of natural 2′-deoxythymidine or 2′-deoxyadenosine are replaced by thiol, amine, or alkylthiol groups. Such nucleosides would be built up into a single DNA strand with cooperative participation of metal coordination, where internucleoside linkages are replaced by metal complexation motifs. The X-ray crystal structure and complexation behaviors of 3′,5′-dithiothymidine, 1, with AuI are also reported.
Synthesis of 3′,5′-dithiothymidine and related compounds
Eleuteri, Alessandra,Reese, Colin B.,Song, Quanlai
, p. 2237 - 2240 (2007/10/03)
When 3′,5′-di-O-mesylthymidine 7 is heated first with Methylamine in ethanol solution and then with the sodium salt of 4-methoxyphenylmethanethiol 9 in N,N-dimethylacetamide (DMA) solution, the bis(sulfide) 11a is obtained in high yield; when the dimesyl
