183480-92-4

Upstream product

• 108311-30-4 C₆₃H₇₃N₈O₁₅P 
• 183480-91-3 N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate 
• 108311-36-0 Carbonic acid (2R,3S,5R)-2-hydroxymethyl-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 68892-41-1 5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine 
• 114745-19-6 2-N-isobutyryl-3'-O-tert-butyldiphenylsilyl-2'-deoxyguanosine 
• 115147-72-3 C₄₄H₅₁N₄O₇P 

Relevant academic research and scientific papers

Synthesis and Characteristics of a Self-Complementary Tetramer d(CGCG) with Methylphosphonate Linkages of Defined Stereochemistry

Starting from protected deoxynucleosides CpG methylphosphonate dimers (p indicating methylphosphonate linkage) were prepared and separated into diastereomers by flash chromatography.The Rp isomer was converted into the β-cyanoethyl phosphoramidite and cou

SEPARATION OF DIASTEREOMERS OF METHYLPHOSPHONATE DINUCLEOTIDES

A chiral derivatizing agent, 1-menthyl chloroformate, has been used as a 3'-OH blocking group to facilitate the resolution of diastereomers of methylphosphonate dinucleotides by silica gel column chromatography.