183484-74-4Relevant academic research and scientific papers
Functionalization of the A ring of pyridoacridine as a route toward greater structural diversity. Synthesis of an octacyclic analogue of eilatin
Bouffier, Laurent,Dinica, Rodica,Debray, Julien,Dumy, Pascal,Demeunynck, Martine
supporting information; experimental part, p. 4836 - 4838 (2010/04/26)
In an effort to increase the structural diversity of pyrido[4,3,2-kl]acridines, compounds containing amino substituents on the A ring were synthesized. The key-reactions involve regioselective electrophilic aromatic substitutions. The methodology was appl
Synthesis of polyfunctionalized Troger's Base analogs derived from ethacridine (6,9-diamino-2-ethoxyacridine)
Tatibouet,Demeunynck,Lhomme
, p. 4375 - 4395 (2007/10/03)
In the search for chemical probes of DNA conformations, we report an efficient synthesis of new Troger's Base analogs derived from polyfunctionalized aminoacridines treated with a stoichiometric amount of formaldehyde in trifluoroacetic acid. For the more sensitive aminoacridines, the Troger's Bases were obtained by nucleophilic substitution of the chloro group of the 'pre-formed' corresponding Troger's Base.
