18354-57-9

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(Thieno[2,3-b]pyridin-5-yl)ethanone serves as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with diverse therapeutic profiles. Its unique structure allows for the exploration of its potential as a lead compound in medicinal chemistry.
Used in Agrochemical Research and Development:
In the agrochemical industry, 1-(Thieno[2,3-b]pyridin-5-yl)ethanone is utilized for the research and development of novel agrochemicals, such as pesticides and herbicides. Its heterocyclic nature may offer new avenues for the design of more effective and environmentally friendly agrochemicals.
Used in Organic Synthesis:
1-(Thieno[2,3-b]pyridin-5-yl)ethanone acts as an important intermediate in organic synthesis, facilitating the preparation of various organic compounds with potential applications in different industries, including materials science, pharmaceuticals, and agrochemicals.
Used in Medicinal Chemistry:
1-(Thieno[2,3-b]pyridin-5-yl)ethanone is employed as a building block in the design and synthesis of new medicinal agents, leveraging its heterocyclic structure to explore its potential therapeutic effects and mechanisms of action.
Used in Neurpharmacology:
Due to its potential biological activities, such as anticonvulsant and sedative effects, 1-(Thieno[2,3-b]pyridin-5-yl)ethanone is studied for its applications in neuropharmacology. It may contribute to the development of new treatments for neurological disorders and conditions related to the central nervous system.

InChI:InChI=1/C9H7NOS/c1-6(11)8-4-7-2-3-12-9(7)10-5-8/h2-5H,1H3

Upstream product

• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 151424-17-8 thiophene amine 
• 609-40-5 2-nitrothiophene 

Downstream Products

• 18354-54-6 5-ethylthieno<2,3-b>pyridine 
• 117390-38-2 thieno<2,3-b>pyridine-5-carboxylic acid 
• 21344-44-5 1-thieno[2,3-b]pyridin-5-yl-ethanone oxime 
• 53566-62-4 1-(3-chloro-thieno[2,3-b]pyridin-5-yl)-ethanone 
• 127019-40-3 3-bromo-5-acetylthieno<2,3-b>pyridine 
• 1400741-57-2 4-methyl-N'-(1-(thieno[2,3-b]pyridin-5-yl)ethylidene)benzenesulfonohydrazide 
• 21344-43-4 thieno[2,3-b]pyridin-5-yl-acetic acid methyl ester 
• 21344-30-9 thieno[2,3-b]pyridine-5-carboxylic acid methyl ester 
• 51043-52-8 N-(5-ethyl-thieno[2,3-b]pyridin-3-yl)-acetamide 
• 51043-51-7 5-ethyl-3-nitro-thieno[2,3-b]pyridine 
• 117390-42-8 N-methyl 5-carbamoyl thieno<2,3-b>pyridinium iodide 
• 117390-40-6 5-carbamoyl thieno<2,3-b>pyridine 
• 108460-24-8 6-carbamoyl 4,7-dihydro thieno<3,2-b>pyridine 
• 108460-23-7 5-carbamoyl 4,7-dihydro thieno<2,3-b>pyridine 

Relevant academic research and scientific papers

Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides

A metal free coupling of heteroaromatic N-tosylhydrazones with thiols is presented. A convenient synthetic route to synthesize heteroaryl N-tosylhydrazones is also showed. Valuable thioethers with pyrroles, pyridines, thieno[2,3-b]pyridines, imidazo[1,2-a]pyridines, and 6H-thieno[2,3-b]pyrroles derivatives were synthesized in good yields. This coupling reaction can be carried out in a one-pot fashion and scaled up to the gram scale by using heteroaryl aldehydes, without the need to isolate the N-tosylhydrazone.

SPIROCYCLIC AZAADAMANTANE DERIVATIVES AND METHODS OF USE

The invention relates to compounds that are spirocyclic azaadamantane derivatives derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

SYNTHESIS, COMPLEXATION STUDY AND REACTIVITY OF ANNELATED THIOPHENIC NADH MODELS.

The synthesis of two carbamoyl 4,7-dihydrothienopyridines 1a and 1b is described.These derivatives are potential new NADH models.A NMR study of the complexation of magnesium ions by these compounds has been performed.The behaviour of the thieno derivative is different of that of thieno derivative: in the former the sulfur atom plays an impotant role in the complexation.The biomimetic reduction of p.nitrobenzaldehyde with 1a or 1b has been studied.The reactivity of the thiophenic annelated NADH models is very superior to that of quinoline analogous.It can be compared to the reactivity of common models such as N-benzyl 1,4-dihydronicotinamide (BNAH).Moreover 1a and 1b can be used in conditions were BNAH is much more less effective.

BIOMIMETIC REDUCTION WITH NON WATER-SENSITIVE NADH MODELS

Two NADH models were synthesized which are considerably less water-sensitive than classical-1,4 dihydronicotinamide derivatives such as N-benzyl-1,4 dihydronicotinamide (BNAH): these two models are reactive and more stable in the presence of water than previously reported models.