183540-25-2Relevant academic research and scientific papers
Pyrrolidinyl hydroxamic acid compounds and their production process
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, (2008/06/13)
A compound of formula (I) STR1 and its pharmaceutically acceptable salt, wherein A is hydrogen or OY, wherein Y is a hydroxy protecting group; Ar is phenyl optionally substituted with one or more substituents selected from halo, hydroxy, C1 -C4 alkyl, C1 -C4 alkoxy, CF3, C1 -C4 alkoxy-C1 -C4 alkyloxy and carboxy-C1 -C4 alkyloxy; X is phenyl, naphthyl, biphenyl, indanyl, benzofuranyl, benzothiophenyl, 1-tetralone-6-yl,C1 -C4 alkylenedioxy, pyridyl, furyl and thienyl these groups optionally being substituted with up to three substituents selected from halo, C1 -C4 alkyl, C1 -C4 alkoxy, hydroxy, NO2, CF3 and SO2 CH3 ; and R is hydrogen, C1 -C4 alkyl or a hydroxy protecting group. These compounds and pharmaceutical compositions containing them are useful as analgesic, anti-inflammatory, diuretic, anesthetic or neuroprotective agents, or an agent for stroke or treatment of functional bowel diseases such as abdominal pain, for the treatment of a mammalian subject, especially a human subject. Further, the present invention provides processes for producing the hydroxamic compounds of formula (I) and their intermediate compounds of the formula. STR2
