183540-68-3Relevant academic research and scientific papers
Ethyl (R)-3-hydroxy-4-phenylthiobutyrate: Synthesis by the bakers' yeast reduction and use as a precursor of enantiomerically pure β-lactam
Hayakawa, Ryuuichirou,Shimizu, Makoto,Fujisawa, Tamotsu
, p. 7533 - 7536 (1996)
The bakers' yeast reduction of ethyl 3-oxo-4-phenylthiobutanoate gave ethyl (R)-3-hydroxy-4-phenylthiobutanoate with >99%ee. The resultant enantiomerically pure alcohol was easily transformed into β-lactam without loss of its enantiomeric purity via the oxamate derivative.
