183545-01-9

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 77300-23-3 cyclohex-(±)-(1R*,4S*)-2-ene-1,4-diyl dibenzoate 

Downstream Products

• 183545-12-2 [(1S,3R,4S)-3-(6-Chloro-pyridin-3-yl)-4-hydroxy-cyclohexyl]-carbamic acid tert-butyl ester 
• 183545-09-7 [(1S,3R)-3-(6-Chloro-pyridin-3-yl)-4-oxo-cyclohexyl]-carbamic acid tert-butyl ester 
• 183545-07-5 [(S)-3-(6-Chloro-pyridin-3-yl)-4-oxo-cyclohex-2-enyl]-carbamic acid tert-butyl ester 
• 183545-03-1 ((S)-3-Bromo-4-oxo-cyclohex-2-enyl)-carbamic acid tert-butyl ester 
• 140111-52-0 epibatidine 
• 183545-02-0 ((S)-4-Oxo-cyclohex-2-enyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Scale-up of azide chemistry: A case study

We report research and development conducted to enable the safe implementation of a highly enantioselective palladium-catalyzed desymmetrization of a meso-bis-ester using trimethylsilylazide (TMSN3) as the nucleophile. This work is used as a ca

An asymmetric synthesis (-)-epibatidine

A Pd catalyzed desymmetrization of cis-3,6-dibenzoyloxy-2-cyclohexene and a Pd catalyzed cross-coupling constitute key reactions in a synthesis of the non-opioid analgesic (-)-epibatidine.