183550-98-3

Basic information

• Product Name: 1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(2R)-3-hydroxy- 2-methylpropyl]-5-(4-methylphenyl)-8-oxo-
• CAS NO: 183550-98-3
• Molecular Formula: C29H25F6N3O3
• Molecular Weight: 577.526
• Mol File: 183550-98-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(2R)-3-hydroxy- 2-methylpropyl]-5-(4-methylphenyl)-8-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(2R)-3-hydroxy- 2-methylpropyl]-5-(4-methylphenyl)-8-oxo-(183550-98-3)
• EPA Substance Registry System: 1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(2R)-3-hydroxy- 2-methylpropyl]-5-(4-methylphenyl)-8-oxo-(183550-98-3)

Safety Data

• Hazardous Substances Data: 183550-98-3(Hazardous Substances Data)

Upstream product

• 183550-77-8 diethyl 5,6-dihydro-5-hydroxy-5-(4-methylphenyl)-8-oxo-8H-pyrano[3,4-b]pyridine-6,6-dicarboxylate 
• 183550-78-9 5-(4-methylphenyl)-8-oxo-8H-pyrano[3,4-b]pyridine-6-carboxylic acid 
• 508210-17-1 8-Oxo-5-p-tolyl-8H-pyrano[3,4-b]pyridine-6-carbonyl chloride 
• 508210-05-7 3-p-toluoyl-pyridine-2-carbonyl chloride 
• 116060-91-4 3-(4-methylbenzoyl)-2-pyridine carboxylic acid 
• 104154-93-0 (R)-3-amino-2-methyl-1-propanol 
• 183550-80-3 N-[3,5-bis(trifluoromethyl)benzyl]-5-(4-methylphenyl)-8-oxo-8H-pyrano[3,4-b]pyridine-6-carboxamide 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE

A compound represented by the formula: wherein ring M is a heterocyclic ring wherein--X=Yis one of--N=C,--CO--N or--CS--N; Ra and Rb are bonded to each other to form Ring A, or they are the same or different and represent, independently, a hydrogen atom or a substituent on the Ring M; Ring A and Ring B represent, independently, an optionally substituted homocyclic or heterocyclic ring, with the proviso that at least one of them is an optionally substituted heterocyclic ring; Ring C is an optionally substituted homocyclic or heterocyclic ring; Ring Z is an optionally substituted nitrogen-containing heterocyclic ring; and n is an integer from 1 to 6, or a salt thereof has a tachykinin receptor antagonistic activity in vitro, and is useful for preventing or treating depression, anxiety, manic-depressive illness or psychopathy.

Axially chiral 1,7-naphthyridine-6-carboxamide derivatives as orally active tachykinin NK1 receptor antagonists: Synthesis, antagonistic activity, and effects on bladder functions

Cyclic analogues of N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-N,7- dimethyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide (1) having a 6-9-membered ring (6-9) were synthesized and evaluated for NK1 antagonistic activities. The 8