183554-00-9

Upstream product

• 284661-57-0 tert-butyl (2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutyl(isobutyl)carbamate 
• 157566-75-1 N-[(1,1-dimethylethoxyl)carbonyl]-N-[2-methylpropyl]-3S-[N₁-(penylmethoxycarbonyl)amino]-2R-hydroxy-4-phenylbutylamine 

Downstream Products

• 1160490-18-5 tert-butyl thiazol-5-ylmethyl (2R,3S)-2-hydroxy-4-phenylbutane-1,3-diyldicarbamate 

Relevant academic research and scientific papers

AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS

The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention further provides the use of said compounds as improvers of the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions are also provided.

Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.