183559-06-0

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 183559-05-9 (2S,4S)-1,5-Dibromo-pentane-2,4-diol 
• 136030-29-0 (2S,4S)-1,5-dichloro-2,4-pentanediol 
• 123-54-6 acetylacetone 

Downstream Products

• 183559-11-7 tert-Butyl-((1S,3S,5S)-1-ethynyl-bicyclo[3.1.0]hex-3-yloxy)-diphenyl-silane 
• 183559-10-6 (1S,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-bicyclo[3.1.0]hexane-1-carbonitrile 
• 182802-00-2 (1S,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-bicyclo[3.1.0]hexane-1-carbaldehyde 
• 183559-18-4 (1R,3aR,7aR)-4-{(E)-2-[(1S,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-bicyclo[3.1.0]hex-1-yl]-vinyl}-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ol 
• 183812-82-0 (1R,3aS,7aR)-4-{(E)-2-[(1S,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-bicyclo[3.1.0]hex-1-yl]-vinyl}-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ol 
• 183559-17-3 (1R,3aR,7aR)-4-[(1S,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-bicyclo[3.1.0]hex-1-ylethynyl]-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ol 
• 183812-81-9 (1R,3aS,7aR)-4-[(1S,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-bicyclo[3.1.0]hex-1-ylethynyl]-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ol 
• 182802-01-3 1-[(1S,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-bicyclo[3.1.0]hex-1-yl]-2-[(1R,3aS,7aR)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol 
• 183900-81-4 1-[(1S,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-bicyclo[3.1.0]hex-1-yl]-2-[(1R,3aR,7aR)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol 

Relevant academic research and scientific papers

A practical synthesis of A-ring precursors for 19-nor-1α,25-dihydroxyvitamin D3 analogues

A convergent, more practical route to the A-ring precursors 3 and 5 starting from enantiopure (2S,4S)-1,2:4,5-diepoxypentane (11) is described.