1835759-75-5

Basic information

• Product Name: t-Butoxycarbonyl-PEG4-NHS ester
• Synonyms: t-Butoxycarbonyl-PEG4-NHS ester;NHS ester-PEG3-t-butyl ester
• CAS NO: 1835759-75-5
• Molecular Formula: C20H33NO10
• Molecular Weight: 447.47672
• Mol File: 1835759-75-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: t-Butoxycarbonyl-PEG4-NHS ester(CAS DataBase Reference)
• NIST Chemistry Reference: t-Butoxycarbonyl-PEG4-NHS ester(1835759-75-5)
• EPA Substance Registry System: t-Butoxycarbonyl-PEG4-NHS ester(1835759-75-5)

Safety Data

• Hazardous Substances Data: 1835759-75-5(Hazardous Substances Data)

Usage

Description

t-Butoxycarbonyl-PEG4-NHS ester is a chemical compound that features a t-Boc protecting group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions, while the NHS ester can react specifically and efficiently with primary amines, such as the side chain of lysine residues or aminosilane-coated surfaces, at neutral or slightly basic conditions to form a covalent bond. The hydrophilic PEG linker enhances the water solubility of the compound in aqueous media.

Uses

Used in Bioconjugation:
t-Butoxycarbonyl-PEG4-NHS ester is used as a bioconjugation agent for the specific and efficient coupling of primary amines, such as lysine residues or aminosilane-coated surfaces, to form stable covalent bonds. This is particularly useful in the development of bioconjugates for various applications, including drug delivery, diagnostics, and therapeutics.
Used in Drug Delivery Systems:
In the pharmaceutical industry, t-Butoxycarbonyl-PEG4-NHS ester is used as a component in drug delivery systems to improve the solubility and stability of therapeutic agents. The hydrophilic PEG linker aids in enhancing the water solubility of the compound, which can be beneficial for the formulation and administration of drugs.
Used in Diagnostics:
In the diagnostics field, t-Butoxycarbonyl-PEG4-NHS ester is used as a reagent for the conjugation of biological molecules, such as antibodies or peptides, to various detection probes. This allows for the development of sensitive and specific diagnostic assays for the detection and quantification of target analytes.
Used in Surface Modification:
In the materials science industry, t-Butoxycarbonyl-PEG4-NHS ester is used for the modification of surfaces, such as aminosilane-coated surfaces, to introduce functional groups or bioactive molecules. This can be useful for creating surfaces with specific properties, such as improved biocompatibility or enhanced binding capabilities, for various applications, including sensors, implants, and lab-on-a-chip devices.