Acid-PEG3-NHS ester is a PEG (polyethylene glycol) linker that features a carboxylic acid and an NHS (N-hydroxysuccinimide) ester. This molecule is designed to enhance solubility in aqueous environments due to the hydrophilic nature of the PEG spacer. The terminal carboxylic acid allows for the formation of stable amide bonds with primary amine groups, facilitated by the presence of activators such as EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) or HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide). Additionally, the NHS ester functionality enables the labeling of primary amines found in proteins, amine-modified oligonucleotides, and other molecules containing amine groups.
1835759-79-9
Post Buying Request-
-
Basic information
- Product Name: Acid-PEG3-NHS ester
- Synonyms: Acid-PEG3-NHS ester;COOH-PEG3-NHS
- CAS NO:1835759-79-9
- Molecular Formula: C14H21NO9
- Molecular Weight: 347.31784
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1835759-79-9.mol
-
Chemical Properties
- Melting Point: N/A
- Boiling Point: 516.1±60.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.34±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in DMSO, DCM, DMF
- PKA: 4.28±0.10(Predicted)
- CAS DataBase Reference: Acid-PEG3-NHS ester(CAS DataBase Reference)
- NIST Chemistry Reference: Acid-PEG3-NHS ester(1835759-79-9)
- EPA Substance Registry System: Acid-PEG3-NHS ester(1835759-79-9)
-
Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1835759-79-9(Hazardous Substances Data)
1835759-79-9 Suppliers
Recommended suppliers
1835759-79-9 Usage
Uses
Used in Bioconjugation:Acid-PEG3-NHS ester is used as a bioconjugation agent for the attachment of various biomolecules to other molecules or surfaces. The reason for this application is its ability to form stable amide bonds with primary amine groups, which facilitates the covalent linkage of proteins, peptides, and other amine-containing molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Acid-PEG3-NHS ester is used as a component in drug delivery systems for the modification of drug molecules. The purpose of this application is to improve the solubility, stability, and bioavailability of drugs, as well as to enable targeted drug delivery by attaching drugs to specific carrier molecules.
Used in Diagnostics and Imaging:
Acid-PEG3-NHS ester is used as a labeling agent in diagnostics and imaging applications. The reason for this application is its ability to label primary amine-containing molecules, such as proteins or oligonucleotides, with various imaging agents or probes, which can then be used for detecting or visualizing specific biological processes or structures.
Used in Research and Development:
In the field of research and development, Acid-PEG3-NHS ester is used as a tool for the synthesis and modification of various biologically active molecules. The reason for this application is its versatility in forming stable amide bonds and its ability to enhance the solubility of the resulting conjugates, which can be crucial for the development of new therapeutic agents or diagnostic tools.
Check Digit Verification of cas no
The CAS Registry Mumber 1835759-79-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,3,5,7,5 and 9 respectively; the second part has 2 digits, 7 and 9 respectively.Calculate Digit Verification of CAS Registry Number 1835759-79:
(9*1)+(8*8)+(7*3)+(6*5)+(5*7)+(4*5)+(3*9)+(2*7)+(1*9)=229
229 % 10 = 9
So 1835759-79-9 is a valid CAS Registry Number.
1835759-79-9Upstream product
1835759-79-9Downstream Products
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 1835759-79-9
Acid-PEG3-NHS ester
