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Acid-PEG4-t-butyl ester is a PEG (polyethylene glycol) linker that features a t-butyl protected carboxyl group with a terminal carboxylic acid. This terminal carboxylic acid has the ability to react with primary amine groups in the presence of activators, such as EDC or HATU, to form a stable amide bond. The hydrophilic PEG spacer enhances solubility in aqueous media, and the t-butyl protected carboxyl group can be deprotected under acidic conditions, making it a versatile molecule for various applications.

1835759-85-7

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1835759-85-7 Usage

Uses

Used in Pharmaceutical Industry:
Acid-PEG4-t-butyl ester is used as a molecular linker for the conjugation of therapeutic agents, such as drugs or peptides, to improve their solubility, stability, and bioavailability. The formation of stable amide bonds with primary amine groups allows for the creation of drug conjugates with enhanced pharmacokinetic properties and reduced immunogenicity.
Used in Drug Delivery Systems:
In the field of drug delivery, Acid-PEG4-t-butyl ester serves as a key component in the design of targeted drug delivery systems. The hydrophilic PEG spacer and the ability to form stable amide bonds enable the development of nanoparticles, liposomes, or other carriers that can selectively deliver therapeutic agents to specific cells or tissues, thereby increasing the efficacy and reducing the side effects of the treatment.
Used in Bioconjugation:
Acid-PEG4-t-butyl ester is used as a bioconjugation agent to attach biologically active molecules, such as antibodies, enzymes, or other proteins, to various surfaces or carriers. The stable amide bond formation ensures the retention of the biological activity of the attached molecules, while the PEG spacer provides steric stabilization and reduces non-specific interactions.
Used in Diagnostics:
In the diagnostics industry, Acid-PEG4-t-butyl ester can be employed to label diagnostic agents, such as imaging agents or biosensors, with PEGylated moieties. This modification can enhance the solubility, circulation time, and biocompatibility of the diagnostic agents, leading to improved performance in various diagnostic applications.
Used in Cosmetics Industry:
Acid-PEG4-t-butyl ester can be utilized in the cosmetics industry as a component of skin care products, where it can improve the solubility and bioavailability of active ingredients, enhance skin hydration, and provide a smooth texture to the formulations.
Used in Material Science:
In material science, Acid-PEG4-t-butyl ester can be used to functionalize surfaces or create PEGylated materials with tailored properties, such as reduced protein adsorption, improved biocompatibility, or controlled release of active agents.

Check Digit Verification of cas no

The CAS Registry Mumber 1835759-85-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,3,5,7,5 and 9 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1835759-85:
(9*1)+(8*8)+(7*3)+(6*5)+(5*7)+(4*5)+(3*9)+(2*8)+(1*5)=227
227 % 10 = 7
So 1835759-85-7 is a valid CAS Registry Number.

1835759-85-7Upstream product

1835759-85-7Downstream Products

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