1835759-88-0

Basic information

• Product Name: Azido-PEG1-methylamine
• Synonyms: Azido-PEG1-methylamine
• CAS NO: 1835759-88-0
• Molecular Formula: C5H12N4O
• Molecular Weight: 144.18
• Mol File: 1835759-88-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Azido-PEG1-methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: Azido-PEG1-methylamine(1835759-88-0)
• EPA Substance Registry System: Azido-PEG1-methylamine(1835759-88-0)

Safety Data

• Hazardous Substances Data: 1835759-88-0(Hazardous Substances Data)

Usage

Description

Azido-PEG1-methylamine is a versatile chemical compound that features an azide group and a methylamine group. The presence of a hydrophilic polyethylene glycol (PEG) spacer enhances its solubility in aqueous media, making it suitable for a range of applications. The azide group is capable of reacting with alkyne, BCN, and DBCO through Click Chemistry, resulting in a stable triazole linkage. Additionally, the methylamine group is reactive with carboxylic acids, activated N-hydroxysuccinimide (NHS) esters, and carbonyls (ketone, aldehyde), further expanding its utility in various chemical reactions and applications.

Uses

Used in Bioconjugation:
Azido-PEG1-methylamine is used as a bioconjugation agent for the formation of stable triazole linkages through Click Chemistry. The azide group's reactivity with alkyne, BCN, and DBCO allows for the efficient and specific attachment of biomolecules, such as proteins, peptides, and other macromolecules, for various biological and pharmaceutical applications.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azido-PEG1-methylamine is used as a component in the design and synthesis of drug delivery systems. The hydrophilic PEG spacer and the reactive groups facilitate the conjugation of drugs to the carrier, improving the solubility, stability, and targeted delivery of therapeutic agents.
Used in Chemical Synthesis:
Azido-PEG1-methylamine is utilized as a building block in the synthesis of various chemical compounds, such as polymers, dendrimers, and other macromolecules. The compound's reactive groups enable the formation of new bonds and the creation of complex structures with tailored properties for specific applications.
Used in Material Science:
In the field of material science, Azido-PEG1-methylamine is employed as a modifier or functional group in the development of new materials with enhanced properties. The compound's reactivity and hydrophilicity can be used to improve the solubility, compatibility, and performance of materials in various applications, such as coatings, adhesives, and composites.
Used in Diagnostics:
Azido-PEG1-methylamine is used as a labeling agent in diagnostic applications, such as immunoassays and molecular imaging. The compound's reactivity with biomolecules allows for the specific and stable attachment of detection markers, enhancing the sensitivity and accuracy of diagnostic tests.