183595-83-7Relevant academic research and scientific papers
Design, synthesis, and evaluation of a novel benzamidine-based inhibitor of VEGF-C binding to Neuropilin-2
Parker, Matthew W.,Said, Ahmed M.,Vander Kooi, Craig W.
, (2020/04/28)
The Neuropilin (Nrp) family of cell surface receptors have key physiological and pathological functions. Nrp2 is of particular interest due to its involvement in tumor metastasis. Currently, peptide and small molecule inhibitors that target Nrp utilize ar
D-Phe-Pro-p-amidinobenzylamine: A potent and highly selective thrombin inhibitor
Wiley, Michael R.,Chirgadze, Nickolay Y.,Clawson, David K.,Craft, Trelia J.,Gifford-Moore, Donetta S.,Jones, Noel D.,Olkowski, Jennifer L.,Weir, Leonard C.,Smith, Gerald F.
, p. 2387 - 2392 (2007/10/03)
The design, synthesis, and enzyme inhibitory profile of D-Phe-Pro-p-Amidinobenzylamine are presented. This compound has inhibitory activity equivalent to D-Phe-Pro-Arg-H, two orders of magnitude more potent than D-Phe-Pro-Agmatine. The results indicate that binding energy provided by the covalent bond of a transition-state analog can be replaced with noncovalent interactions.
