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Leukomycin A8 is a cytotoxic polyketide compound produced by the soil bacterium Streptomyces through a type I polyketide synthesis pathway. It is a member of a class of antibiotics that exhibit significant anticancer activity across various tumor models. Leukomycin A8 is notable for its capacity to induce cell cycle arrest and promote apoptosis in cancer cells, positioning it as a promising candidate for the development of anti-cancer drugs. Leukomycin A8's mechanism of action involves the inhibition of cancer cell proliferation by targeting essential signaling pathways that regulate cell growth and survival. Its selectivity for cancer cells over normal cells is a valuable attribute for potential therapeutic applications in oncology.

18361-50-7

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18361-50-7 Usage

Uses

Used in Pharmaceutical Industry:
Leukomycin A8 is used as an anticancer agent for its ability to selectively target and inhibit the growth of cancer cells. It is particularly effective in inducing cell cycle arrest and apoptosis, which are critical for controlling tumor progression.
Used in Cancer Research:
In the field of cancer research, Leukomycin A8 serves as a valuable tool for studying the molecular mechanisms underlying cancer cell growth and survival. Its impact on key signaling pathways provides insights into potential therapeutic targets for cancer treatment.
Used in Drug Development:
Leukomycin A8 is utilized in the development of novel anticancer drugs due to its potent activity against various types of cancer cells. Its selectivity and mechanism of action offer a promising foundation for creating more effective and targeted cancer therapies.
Used in Combination Therapy:
Leukomycin A8 is also considered for use in combination therapies with other anticancer agents. Its ability to target specific pathways in cancer cells may enhance the effectiveness of existing treatments and overcome resistance issues in cancer therapy.

Check Digit Verification of cas no

The CAS Registry Mumber 18361-50-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,3,6 and 1 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 18361-50:
(7*1)+(6*8)+(5*3)+(4*6)+(3*1)+(2*5)+(1*0)=107
107 % 10 = 7
So 18361-50-7 is a valid CAS Registry Number.
InChI:InChI=1/C39H63NO15/c1-21-18-27(16-17-41)35(36(48-10)29(52-25(5)42)19-30(45)49-22(2)14-12-11-13-15-28(21)44)55-38-33(46)32(40(8)9)34(23(3)51-38)54-31-20-39(7,47)37(24(4)50-31)53-26(6)43/h11-13,15,17,21-24,27-29,31-38,44,46-47H,14,16,18-20H2,1-10H3/b12-11+,15-13+/t21-,22-,23-,24+,27+,28+,29-,31+,32-,33-,34-,35+,36+,37+,38+,39-/m1/s1

18361-50-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name [(11Z,13E)-6-[5-(5-acetyloxy-4-hydroxy-4,6-dimethyloxan-2-yl)oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl] acetate

1.2 Other means of identification

Product number -
Other names Turimycin A2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18361-50-7 SDS

18361-50-7Upstream product

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