183617-22-3

Upstream product

• 14204-24-1 N-(phenylthio)succinimide 
• 183617-21-2 [(1S,2R,1'R,2'R,1''S,2''R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,1';2',1'']tercyclopropan-2''-yl]-methanol 
• 183815-11-4 (E)-3-[(1R,2S,1'S,2'R)-2'-(tert-Butyl-dimethyl-silanyloxymethyl)-bicyclopropyl-2-yl]-acrylic acid ethyl ester 
• 176168-09-5 (1R,3S,4S,6R)-1,6-bis(hydroxymethyl)bicyclopropane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 183617-20-1 (E)-3-[(1R,2S,1'S,2'R)-2'-(tert-Butyl-dimethyl-silanyloxymethyl)-bicyclopropyl-2-yl]-prop-2-en-1-ol 
• 183617-18-7 [(1S,2R,1'S,2'R)-2'-(tert-Butyl-dimethyl-silanyloxymethyl)-bicyclopropyl-2-yl]-methanol 

Relevant academic research and scientific papers

Total synthesis of the pentacyclopropane antifungal agent FR-900848

Quatercyclopropane 31 was oxidized, homologated, reduced, and monocyclopropanated to provide the pentacyclopropane alcohol 35. Subsequent deoxygenation of alcohol 35 was effected using N-(phenylthio)succinimide (24) and tributylphosphine followed by Raney