183624-99-9

Upstream product

• 183624-93-3 (3R,3aR,6R,6aR)-6-benzyloxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 
• 183624-97-7 (3R,3aR,6R,6aR)-3-Allyloxy-6-benzyloxy-hexahydro-furo[3,2-b]furan 

Relevant academic research and scientific papers

Preparation and use of chiral (Z)-enol ethers in asymmetric Bradsher cycloaddition

Chiral (Z)-enol ethers 7a-7p have been prepared in two steps. Bradsher cycloaddition between such compounds and 2,7-naphthyridinium salt 4b in water or in ter-butanol-water afforded, in some cases with good yield and diastereoselectivity, highly functionalized isoquinoline derivatives, potential intermediates in Manzamine A 1 total synthesis. X-Ray analysis secured the direction of asymmetric induction with enol ether 7l.