183660-33-5

Basic information

• Product Name: Cyclopropanemethanamine, 1-[3-(cyclopentyloxy)-4-methoxyphenyl]-
• CAS NO: 183660-33-5
• Molecular Formula: C16H23NO2
• Molecular Weight: 261.364
• Mol File: 183660-33-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclopropanemethanamine, 1-[3-(cyclopentyloxy)-4-methoxyphenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanemethanamine, 1-[3-(cyclopentyloxy)-4-methoxyphenyl]-(183660-33-5)
• EPA Substance Registry System: Cyclopropanemethanamine, 1-[3-(cyclopentyloxy)-4-methoxyphenyl]-(183660-33-5)

Safety Data

• Hazardous Substances Data: 183660-33-5(Hazardous Substances Data)

Upstream product

• 141333-36-0 4-cyanomethyl-2-cyclopentyloxy-1-methoxybenzene 
• 175206-66-3 4-chloromethyl-2-cyclopentyloxy-1-methoxybenzene 
• 133332-49-7 (3-cyclopentyloxy-4-methoxyphenyl)methanol 
• 67387-76-2 3-cyclopentyloxy-4-methoxybenzylaldehyde 
• 183660-31-3 1-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclopropanecarbonitrile 

Relevant articles and documents

Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.

This communication describes the synthesis and in vitro PDE4 inhibitory activity of a novel series of imidazol-2-one and 2-cyanoiminoimidazole derivatives. The compounds described were also tested in in vivo models to evaluate their anti-inflammatory activity after topical administration as well as their gastro-intestinal side effects. Several compounds proved to be potent PDE4 inhibitors and some 2-cyanoiminoimidazoles showed less pronounced gastro-intestinal side effects than reference compounds but maintained anti-inflammatory activity after topical administration.