1837-55-4

Basic information

• Product Name: 3,5-Dichloropyridazine
• Synonyms: 3,5-Dichloropyridazine;SA029519;Pyridazine,3,5-dichloro-
• CAS NO: 1837-55-4
• Molecular Formula: C₄H₂Cl₂N₂
• Molecular Weight: 148.98
• Mol File: 1837-55-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 60.0 to 64.0 °C
• Boiling Point: 280.8 °C at 760 mmHg
• Flash Point: 150.5 °C
• Appearance: /
• Density: 1.493 g/cm³
• Vapor Pressure: 0.00629mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: -0.25±0.10(Predicted)
• CAS DataBase Reference: 3,5-Dichloropyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloropyridazine(1837-55-4)
• EPA Substance Registry System: 3,5-Dichloropyridazine(1837-55-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 1837-55-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1837-55-4 differently. You can refer to the following data:
1. 3,5-Dichloropyridazine used in the treatment of asthma and allergy. Potential for antinociceptive and antiinflammatory effects
2. 3,5-Dichloropyridazine acts as a novel histamine H4 antagonist used in the treatment of asthma and allergy. Potential for antinociceptive and antiinflammatory effects.

InChI:InChI=1/C4H2Cl2N2/c5-3-1-4(6)8-7-2-3/h1-2H

Upstream product

• 1081808-80-1 (Z)-2,4,4,4-tetrachlorobut-2-enal 
• 19429-51-7 2,4,4,4-tetrachloro-but-2-enal 

Downstream Products

• 2096-20-0 3,5-dimethoxypyridazine 
• 29049-45-4 3-chloro-5-aminopyridazine 
• 86663-08-3 3-chloro-5-phenyl-pyridazine 

Relevant articles and documents

Energetic Functionalization of the Pyridazine Scaffold: Synthesis and Characterization of 3,5-Diamino-4,6-dinitropyridazine-1-Oxide

The synthesis of 3,5-diamino-4,6-dinitropyridazine-1-oxide (8) is reported. It is prepared in a six-step synthetic procedure starting from acyclic compounds, and shows good properties (detonation velocity DC–J = 8486 m s–1, detonation pressure pC–J = 302 kbar), and sensitivity toward mechanical stimuli. Compound 8 and its precursor (7, 3,5-dimethoxy-4,6-dinitropyridazine-1-oxide) were characterized by means of multinuclear (1H, 13C, 14N, 15N) NMR spectroscopy, mass spectrometry, vibrational spectroscopy (IR and Raman), elemental analysis and differential thermal analysis (DTA) measurements. Compounds 4, 5, 6, 7, 8 and 9 were also characterized by low-temperature single-crystal X-ray diffraction. The heats of formation for 7 and 8 were calculated using the atomization method based on CBS-4M enthalpies. Using the experimentally determined (X-ray) densities and the calculated standard molar enthalpies of formation, several detonation parameters such as the detonation pressure, energy and velocity were predicted by using the EXPLO5 code (V6.03). The sensitivities of 3,5-dimethoxy-4,6-dinitropyridazine-1-oxide (7) and 3,5-diamino-4,6-dinitropyridazine-1-oxide (8) toward impact, friction and electrical discharge were tested according to BAM standards. In addition, the shock reactivity of 8 was measured by applying the small-scale shock reactivity test, showing similar values to HNS, PYX and TKX-55.

GPR52 MODULATOR COMPOUNDS

The disclosures herein relate to novel compounds of Formula (1): (1) and salts thereof, wherein R1, Q, X, Y and Z are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.