18372-11-7

Basic information

• Product Name: 3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid
• Synonyms: 3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid;Coproporphyrin IV;3,7,12,18-Tetramethyl-21H,23H-porphyrin-2,8,13,17-tetrapropionic acid
• CAS NO: 18372-11-7
• Molecular Formula: C₃₆H₃₈N₄O₈
• Molecular Weight: 654.70892
• Mol File: 18372-11-7.mol

Chemical Properties

• Boiling Point: 1264.7°Cat760mmHg
• Flash Point: 718.7°C
• Appearance: /
• Density: 1.366g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid(18372-11-7)
• EPA Substance Registry System: 3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid(18372-11-7)

Safety Data

• Hazardous Substances Data: 18372-11-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C36H38N4O8/c1-17-21(5-9-33(41)42)29-14-27-19(3)23(7-11-35(45)46)31(39-27)16-32-24(8-12-36(47)48)20(4)28(40-32)15-30-22(6-10-34(43)44)18(2)26(38-30)13-25(17)37-29/h13-16,39-40H,5-12H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-

Upstream product

• 59969-39-0 coproporphyrinogen lV 

Downstream Products

• 5522-66-7 3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionic acid dimethyl ester 

Relevant articles and documents

Biosynthesis of Porphyrins and Related Macrocycles. Part 15. Chemical and Enzymic Formation of Uroporphyrinogen Isomers from Unrearranged Aminomethylpyrromethane: Separation of Isomeric Coproporphyrin Esters

The unrearranged pyrromethane (1) is transformed chemically mainly into uro'gen-I with a smaller amount of uro'gen-IV but only traces of uro'gen-III are formed.Uro'gen-I is produced via a tetrapyrrolic (bilane) intermediate and when the diaminase-cosynthetase enzyme system from Euglena gracilis is present, this intermediate is converted into uro'gen-III.The rearrangement step for this conversion has the same characteristics found earlier for the natural biosynthetic process from porphobilinogen.Pyrromethane (1) is not a direct biosynthetic precursor of uro'gen-III and reasons are advanced why this is understandable.Methods are developed based on high pressure liquid chromatography for the separation of all four isomeric coproporphyrin esters.

Biosynthesis of Porphyrins and Related Macrocycles. Part 13. Structure of the Protoporphyrin Isomer derived from Coproporphyrinogen lV by the Action of Beef-Liver Coproporphyrinogenase: Synthesis of Protoporphyrin Xlll

Coproporphyrinogen lV (8) is synthesised and is oxidatively decarboxylated by coproporphyrinogenase from beef-liver to produce, after aromatisation, a porphyrin proved to be protoporphyrin Xlll (11) by spectroscopy and by unambiquous synthesis; the synthesis route is described.A monovinylporphyrin, derived from an intermediate for the conversion (8) -> (11), is also isolated.The importance of these results for earlier biosynthetic studies with pyrromethanes is discussed.