183720-43-6Relevant articles and documents
Synthesis and structure-activity relationships of 3-aryloxindoles: A new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties
Hewawasam, Piyasena,Erway, Matthew,Moon, Sandra L.,Knipe, Jay,Weiner, Harvey,Boissard, Christopher G.,Post-Munson, Debra J.,Gao, Qi,Huang, Stella,Gribkoff, Valentin K.,Meanwell, Nicholas A.
, p. 1487 - 1499 (2007/10/03)
A series of 3-aryloxindole derivatives were synthesized and evaluated as activators of the cloned maxi-K channel mSlo expressed in Xenopus laevis oocytes using electrophysiological methods. The most promising maxi-K openers to emerge from this study were
The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels
Hewawasam, Piyasena,Gribkoff, Valentin K.,Pendri, Yadagiri,Dworetzky, Steven I.,Meanwell, Nicholas A.,Martinez, Eduardo,Boissard, Christopher G.,Post-Munson, Debra J.,Trojnacki, Joanne T.,Yeleswaram, Krishnaswamy,Pajor, Lorraine M.,Knipe, Jay,Gao, Qi,Perrone, Robert,Starrett Jr., John E.
, p. 1023 - 1026 (2007/10/03)
3-Aryl-3-fluorooxindoles can be efficiently synthesized in two steps by the addition of an aryl Grignard to an isatin, followed by treatment with DAST. Oxindole 1 (BMS-204352; MaxiPost) can be isolated using chiral HPLC or prepared by employing chiral res