183730-32-7Relevant articles and documents
Synthesis of a magnosalin derivative, 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylaminopyrimidine, and the anti-angiogenic and anti-rheumatic effect on mice by oral administration.
Tanaka, Katsunao,Konno, Yasuo,Kuraishi, Yasushi,Kimura, Ikuko,Suzuki, Takashi,Kiniwa, Mamoru
, p. 623 - 627 (2002)
We describe here the synthesis and the anti-angiogenic and anti-rheumatic activities of 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylaminopyrimidine (TAS-202), a derivative of magnosalin, which is a natural product isolated from Flos magnoliae. TAS-202 inhibited the proliferation of vascular endothelial cells more potently than magnosalin, and when given orally it inhibited basic fibroblast growth factor (bFGF)-induced angiogenesis and collagen-induced arthritis in mice. This magnosalin derivative with anti-angiogenic effects is a candidate for the treatment of rheumatoid arthritis.
Total synthesis of moniliformediquinone and calanquinone A as potent inhibitors for breast cancer
Thangaraj, Shankar,Tsao, Wen-Shing,Luo, Yi-Wei,Lee, Yean-Jang,Chang, Chia-Fu,Lin, Chun-Cheng,Uang, Biing-Jiun,Yu, Chia-Chun,Guh, Jih-Hwa,Teng, Che-Ming
experimental part, p. 6166 - 6172 (2011/09/19)
The first synthesis of moniliformediquinone has been achieved in which the longest linear sequence is only nine steps. The synthesis proceeds in 23% overall yield from commercially available 2,4,5-trimethoxybenzaldehyde. The key transformations include a
