183730-71-4Relevant articles and documents
Synthesis of glycoconjugates of the globo-H epitope and uses thereof
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, (2008/06/13)
The present invention provides a method of synthesizing a compound having the structure: as well as other related glycoconjugates useful as vaccines for inducing antibodies to epithelial cancer cells in an adjuvant therapy therefore, and in a method for preventing recurrence of epithelial cancer. The present invention also provides a vaccine comprising an amount of the compound described above effective to prevent the recurrence of cancer in a subject.
Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
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, (2008/06/13)
The present invention provides a process for synthesizing a compound having the structure: STR1 wherein R is H, as well as related oligosaccharides useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant therapy therefor.
Synthesis of asparagine-linked glycopeptides on a polymeric solid support
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, (2008/06/13)
The present invention provides a process for synthesizing a glycopeptide having the structure: STR1 wherein R1, R2, R3, R4, R5, R6, R7 and R8 are each independently H,
Total synthesis and proof of structure of a human breast tumor (globo-H) antigen
Park, Tae Kyo,Kim, In Jong,Hu, Shuanghua,Bilodeau, Mark T.,Randolph, John T.,Kwon, Ohyun,Danishefsky, Samuel J.
, p. 11488 - 11500 (2007/10/03)
The total synthesis of the Hakomori MBr1 antigen, heavily expressed on human breast tumors, is related. The construction involved the assembly of four glycals: (17 (twice), 18, 20, and 26) and an L-fucose derivative, 34. The sensitivity of the stereochemi