183736-74-5

Basic information

• Product Name: 6-chloro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid
• Synonyms: 2H-1-Benzopyran-3-carboxylic acid, 6-chloro-7-hydroxy-2-oxo-; 6-Chloro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid
• CAS NO: 183736-74-5
• Molecular Formula: C₁₀H₅ClO₅
• Molecular Weight: 240.5967
• Mol File: 183736-74-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 479.2°C at 760 mmHg
• Flash Point: 243.6°C
• Density: 1.747g/cm³
• Vapor Pressure: 5.4E-10mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 6-chloro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid(183736-74-5)
• EPA Substance Registry System: 6-chloro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid(183736-74-5)

Safety Data

• Hazardous Substances Data: 183736-74-5(Hazardous Substances Data)

Usage

Type

Synthetic antibiotic compound

Antibacterial Activity

Potent

Class

Coumarin derivatives

Mechanism of Action

Inhibiting the DNA gyrase enzyme in bacteria

Potential Uses

Treatment of bacterial infections, including multidrug-resistant strains and antitumor activity for cancer therapy.

Upstream product

• 141-82-2 malonic acid 
• 131088-02-3 2,4-dihydroxy-5-chlorobenzaldehyde 
• 912771-34-7 5-chloro-2,4-dimethoxybenzaldehyde 
• 7051-13-0 1-chloro-2,4-dimethoxybenzene 
• 2033-24-1 cycl-isopropylidene malonate 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 95-88-5 4-Chlororesorcinol 
• 856106-90-6 5-chloro-2,4-bis-methoxycarbonyloxy-benzaldehyde 

Downstream Products

• 183736-47-2 7-butyryloxy-3-carboxy-6-chlorocoumarin 
• 183736-75-6 7-butyryloxy-3-benzyloxycarbonylmethylaminocarbonyl-6-chlorocoumarin 
• 688044-40-8 {tert-butoxycarbonylmethyl-[4-({6-chloro-7-[1-(2-nitro-phenyl)-ethoxy]-2-oxo-2H-chromene-3-carbonyl}-amino)-cyclohexyl]-amino}-acetic acid tert-butyl ester 
• 688044-29-3 2-{[6-chloro-7-(4,5-dimethoxy-2-nitro-benzyloxy)-2-oxo-2H-chromene-3-carbonyl]-amino}-pentanedioic acid dimethyl ester 
• 688044-39-5 (tert-butoxycarbonylmethyl-{4-[(6-chloro-7-hydroxy-2-oxo-2H-chromene-3-carbonyl)-amino]-cyclohexyl}-amino)-acetic acid tert-butyl ester 
• 87893-58-1 6-chloro-7-hydroxy-coumarin 

Relevant articles and documents

Fluorescently Labeled Amino Acids as Building Blocks for Bioactive Molecules

A series of twelve fluorescently labeled amino acids were designed by assembling different coumarin, fluorescein, or nitrobenzo-furazan fluorophores with N-protected lysine or 2-aminopropionic acid. The synthesized amino acids were evaluated with regard to their spectroscopic properties. The easy introduction of the amino acids into peptides and peptidomimetics was exemplarily shown for one coumarin-labeled- amino acid.

Photodegradable hydrogels to generate positive and negative features over multiple length scales

Here we present a photodegradable hydrogel as a biocompatible, nonfouling photoresist capable of presenting positive and negative features through single-photon and two-photon degradation. An ortho-nitrobenzylether (o-NBE) moiety is used as a polymerizabl

Synthesis and photochemical properties of a light-activated fluorophore to label His-tagged proteins

Rapid and efficient light-induced fluorescence enhancement is demonstrated on a DMNPB-"caged" coumarin derivative carrying a His-tag recognition motif. The Royal Society of Chemistry.