183738-77-4Relevant academic research and scientific papers
Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines
Traxler, Peter,Bold, Guido,Frei, Joerg,Lang, Marc,Lydon, Nicholas,Mett, Helmut,Buchdunger, Elisabeth,Meyer, Thomas,Mueller, Marcel,Furet, Pascal
, p. 3601 - 3616 (2007/10/03)
In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP- competitive inhibitors interacting w
