183740-30-9

Upstream product

• 71026-66-9 N-(tert-butoxycarbonyl)-1,4-phenylenediamine 
• 5147-80-8 [Bis(methylthio)methylene]malononitrile 

Downstream Products

• 183740-32-1 5-amino-3-[4-(N-BOC-amino)-phenylamino]-4-cyano-pyrazole 
• 183739-03-9 3-[4-(N-BOC-amino)-phenylamino]-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine 
• 183740-36-5 1,5-dihydro-3-[4-(N-BOC-amino)-phenylamino]-4-imino-5-(3-chloro-phenyl)-4H-pyrazolo[3,4-d]pyrimidine 

Relevant academic research and scientific papers

Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP- competitive inhibitors interacting w