183742-34-9

Basic information

• Product Name: 4-Boc-1-Fmoc-2-Piperazine acetic acid
• Synonyms: N-4-BOC-N-1-FMOC-2-PIPERAZINE ACETIC ACID;1-FMOC-4-BOC-PIPERAZINE-2-ACETIC ACID;2-CARBOXYMETHYL-PIPERAZINE-1,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 1-(9H-FLUOREN-9-YLMETHYL) ESTER;1-N-FMOC-4-N-BOC-PIPERAZINE-2-ACETIC ACID;4-[(9H-FLUOREN-9-YLOXY)CARBONYL]-1-(TERT-BUTOXYCARBONYL)PIPERAZYL-2-ACETIC ACID;(R)-N-1-BOC-N-4-FMOC-2-PIPERAZINE CARBOXYLIC ACID;2-[1-(9H-Fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-2-yl]acetic acid;4-Boc-1-Fmoc-2-Piperazine acetic acid
• CAS NO: 183742-34-9
• Molecular Formula: C26H30N2O6
• Molecular Weight: 466.53
• Product Categories: pharmacetical;Carboxylic Acids;Pyrans, Piperidines &Piperazines;Carboxylic Acids;Pyrans, Piperidines & Piperazines
• Mol File: 183742-34-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 637.4 °C at 760 mmHg
• Flash Point: 339.3 °C
• Appearance: /
• Density: 1.261 g/cm³
• Vapor Pressure: 4.03E-17mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 4.67±0.10(Predicted)
• CAS DataBase Reference: 4-Boc-1-Fmoc-2-Piperazine acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Boc-1-Fmoc-2-Piperazine acetic acid(183742-34-9)
• EPA Substance Registry System: 4-Boc-1-Fmoc-2-Piperazine acetic acid(183742-34-9)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 183742-34-9(Hazardous Substances Data)

Usage

Uses

N-4-Boc-N-1-Fmoc-2-piperazine Acetic Acid was determined to be a potential tricyclic farnesyltransferase inhibitor using ECliPs libraries.

InChI:InChI=1/C26H30N2O6/c1-26(2,3)34-24(31)27-12-13-28(17(15-27)14-23(29)30)25(32)33-16-22-20-10-6-4-8-18(20)19-9-5-7-11-21(19)22/h4-11,17,22H,12-16H2,1-3H3,(H,29,30)/p-1/t17-/m0/s1

Downstream Products

• 1252645-84-3 1-(9H-fluoren-9-yl)methyl 4-tert-butyl 2-(2-(2-bromophenylamino)-2-oxoethyl)piperazine-1,4-dicarboxylate 

Relevant articles and documents

CARBONYL-PIPERAZINYL AND PIPERIDINIL COMPOUNDS WHICH INHIBIT FARNESYL PROTEIN TRANSFERASE

Novel carbonyl piperazinyl and piperidinyl compounds of formula (1.0) or (1.1) and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth cells in a mammal such as the human being. A compound of formula (1.0) and (1.1) or a pharmaceutically acceptable salt or solvate thereof, wherein Z is a group which is (i), (ii) or (iii), wherein X1 is CH or N; X2 can be the same or different and can be CH, N, or N-O; b is 0, 1, 2, 3, 4; n and nn independently represent 0, 1, 2, 3, 4 or when X2 is CH, n and nn can be 5; R20 and R21, R1, R2 and R3 are as given in the description.

Carbonyl piperazinyl and piperidinyl compounds

Novel carbonyl piperazinyl and piperidinyl compounds and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.