18377-79-2Relevant academic research and scientific papers
Kinetics of Alkylation Reactions of Pyrrolizidine Alkaloid Pyrroles
Karczesy, J. J.,Arbogast, B.,Deinzer, M. L.
, p. 3867 - 3872 (2007/10/02)
Pyrrolizidine alkaloid pyrrolws react rapidly with 4-(p-nitrobenzyl)pyridine under pseudo-first order conditions.A biexpotential first-order rate law is observed.Relative reactivities are grewatly influenced by the nature of the leaving group at C7. 2,3-Dihydro-1H-pyrrolizin-1-ol and dehydrosupinidine under pseudo-first-order reaction conditions obey a simple first-order rate expression.Evidence for oligomerization of the pyrrolizidine pyrrole nucleus has been obtained under these reaction conditions, and it is proposed that a second color-forming reaction sequence of nucleophile with the oligomer C9s accounts for the biexpotential rate law.
