183800-35-3

Basic information

• Product Name: (2R,3R)-2-(2,4-Difluorophenyl)-3-[trans-2-[4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]buta-1(E),3(E)-dienyl]-1,3-dioxan-5-ylsulfanyl]-1-(1,2,4-triazol-1-yl)-2-butanol
• Synonyms: R-102557
• CAS NO: 183800-35-3
• Molecular Formula: C₂₉H₂₉F₆N₃O₄S
• Molecular Weight: 629.62658
• Mol File: 183800-35-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3R)-2-(2,4-Difluorophenyl)-3-[trans-2-[4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]buta-1(E),3(E)-dienyl]-1,3-dioxan-5-ylsulfanyl]-1-(1,2,4-triazol-1-yl)-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-2-(2,4-Difluorophenyl)-3-[trans-2-[4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]buta-1(E),3(E)-dienyl]-1,3-dioxan-5-ylsulfanyl]-1-(1,2,4-triazol-1-yl)-2-butanol(183800-35-3)
• EPA Substance Registry System: (2R,3R)-2-(2,4-Difluorophenyl)-3-[trans-2-[4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]buta-1(E),3(E)-dienyl]-1,3-dioxan-5-ylsulfanyl]-1-(1,2,4-triazol-1-yl)-2-butanol(183800-35-3)

Safety Data

• Hazardous Substances Data: 183800-35-3(Hazardous Substances Data)

Upstream product

• 183800-59-1 (2R,3R)-2-(2,4-difluorophenyl)-3-[(trans-2-phenyl-1,3-dioxan-5-yl)thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 183800-91-1 ethyl (2E,4E)-5-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2,4-pentadienoate 
• 183800-92-2 (2E,4E)-5-[4-(2,2,3,3-Tetrafluoropropoxy)phenyl]-2,4-pentadien-1-ol 
• 103962-17-0 4-(2,2,3,3-tetrafluoropropoxy)-benzaldehyde 
• 32295-56-0 S-(trans-2-phenyl-1,3-dioxane-5-yl) thioacetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 183800-93-3 (2E,4E)-5-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2,4-pentadienal 
• 183800-60-4 (2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol 

Relevant articles and documents

Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives

Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11 - 13 under acidic conditions afforded a series of dioxane-triazole compounds 14 - 16. The antifungal activities of the compounds 14 - 16 were evaluated in vivo in mice infection models against Candida and Aspergillus species. High activities were seen for the derivatives with one or two double bond(s) and an aromatic ring substituted with an electron-withdrawing group in the side chain. Among the derivatives, R-102557 (16R: Ar=4-(2,2,3,3- tetrafluoropropoxy)phenyl) showed excellent in vivo activities against Candida, Aspergillus and Cryptococcus species. It also showed high tolerance in a preliminary toxicity study in rats.