183811-07-6

Basic information

• Product Name: Pyrimidine, 4,6-dichloro-5-(phenylthio)-
• CAS NO: 183811-07-6
• Molecular Formula: C10H6Cl2N2S
• Molecular Weight: 257.143
• Mol File: 183811-07-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrimidine, 4,6-dichloro-5-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 4,6-dichloro-5-(phenylthio)-(183811-07-6)
• EPA Substance Registry System: Pyrimidine, 4,6-dichloro-5-(phenylthio)-(183811-07-6)

Safety Data

• Hazardous Substances Data: 183811-07-6(Hazardous Substances Data)

Upstream product

• 108-98-5 thiophenol 
• 15726-38-2 5-bromo-4,6-dihydroxypyrimidine 
• 183811-08-7 5-phenylsulfanyl-pyrimidine-4,6-diol 

Downstream Products

• 385370-19-4 5-benzenesulfinyl-4,6-dichloro-pyrimidine 
• 385370-20-7 5-benzenesulfonyl-4,6-dichloro-pyrimidine 

Relevant articles and documents

Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors

Adenosine kinase (AK) is the primary enzyme responsible for adenosine metabolism. Inhibition of AK effectively increases extracellular adenosine concentrations and represents an alternative approach to enhance the beneficial actions of adenosine as compared to direct-acting receptor agonists. Clitocine (3), isolated from the mushroom Clitocybe inversa, has been found to be a weak inhibitor of AK. We have prepared a number of analogues of clitocine in order to improve its potency and demonstrated that 5′-deoxy-5′-amino-clitocine (7) improved AK inhibitory potency by 50-fold.