183853-93-2Relevant academic research and scientific papers
Synthesis and evaluation of the hybrid molecules possessing DNA-cleaving activity
Shishido, Kozo,Haruna, Shigenori,Yamamura, Chisato,Iitsuka, Hiromi,Nemoto, Hisao,Shinohara, Yasuo,Shibuya, Masayuki
, p. 2617 - 2622 (2007/10/03)
The design and synthesis of enantiomerically enriched hybrid molecules, 1a-c and 2a-c, have been accomplished by employing the lipase-mediated asymmetric acetylation of prochiral diol 9 as the key step. Evaluation of their DNA-cleaving activity has revealed the unnatural type of enantiomer 2a-c to be more potent than 1a-c with natural configuration.
