18386-00-0

Basic information

• Product Name: 4-methoxy-2-hydroxycinnamaldehyde
• Synonyms: 4-methoxy-2-hydroxycinnamaldehyde
• CAS NO: 18386-00-0
• Molecular Weight: 178.188
• Mol File: 18386-00-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-methoxy-2-hydroxycinnamaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-2-hydroxycinnamaldehyde(18386-00-0)
• EPA Substance Registry System: 4-methoxy-2-hydroxycinnamaldehyde(18386-00-0)

Safety Data

• Hazardous Substances Data: 18386-00-0(Hazardous Substances Data)

Upstream product

• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 2136-75-6 (triphenylphosphoranylidene)acetaldehyde 

Downstream Products

• 531-59-9 7-methoxycoumarin 
• 20921-02-2 7-methoxy-3,4-dihydro-2H-1-benzopyran-2-one 

Relevant articles and documents

Application of E1cB Elimination in Asymmetric Organocatalytic Cascade Reactions to Construct Polyheterocyclic Compounds

By introducing a carbon functionality at 2-position of chromane, the formal asymmetric functionalization of the 3-position of 2-substituted chromane has been realized via a highly chemo-, regio-, and stereoselective organocatalytic cascade reaction in a sequential one-pot manner involving an E1cB mechanism governed ring-opening process. Critical to our success was the design of a chiral dipeptide-based bifunctional acid-base organocatalyst, which exhibited high catalytic activity at low catalyst loading (1-0.1 mol %), leading to biologically interesting polyheterocyclic compounds.

Bi(OTf)3-catalyzed addition of isocyanides to 2: H -chromene acetals: An efficient pathway for accessing 2-carboxamide-2 H -chromenes

Bismuth triflate (Bi(OTf)3) is identified as an efficient catalyst for the direct addition of isocyanides to 2H-chromene acetals. The large scope of isocyanides and chromene acetals makes them suitable substrates in this catalytic system. By this synthetic strategy, a polyfunctional molecular scaffold, 2-carboxamide-2H-chromenes could be prepared efficiently in one step up to 95% yield. In addition, this efficient and practical protocol proceeded smoothly in the gram scale even when the catalytic loading was reduced to 2 mol%.

An efficient carbene-catalyzed access to 3,4-dihydrocoumarins

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