183860-46-0Relevant articles and documents
HIV protease inhibitory bis-benzamide cyclic ureas: A quantitative structure-activity relationship analysis
Wilkerson, Wendell W.,Akamike, Emeka,Cheatham, Walter W.,Hollis, Andrea Y.,Collins, R. Dale,DeLucca, Indawati,Lam, Patrick Y. S.,Ru, Yu
, p. 4299 - 4312 (2007/10/03)
A series of N,N'-disubstituted cyclic urea 3-benzamides has been synthesized and evaluated for HIV protease inhibition and antiviral activity. Some of these benzamides have been shown to be potent inhibitors of HIV protease with K(i) 90 20 nM for viral replication and, as such, may be useful in the treatment of AIDS. The synthesis and quantitative structure activity relationship for this benzamide series will be discussed.