183864-47-3Relevant academic research and scientific papers
Catalyst for aromatic C—O, C—N, and C—C bond formation
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, (2008/06/13)
The present invention is directed to a transition metal catalyst, comprising a Group 8 metal and a ligand having the structure wherein R, R′ and R″ are organic groups having 1-15 carbon atoms, n=1-5, and m=0-4. The present invention is also directed to a method of forming a compound having an aromatic or vinylic carbon-oxygen, carbon-nitrogen, or carbon-carbon bond using the above catalyst. The catalyst and the method of using the catalyst are advantageous in preparation of compounds under mild conditions of approximately room temperature and pressure.
Gem-dialkyl-7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
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, (2008/06/13)
Gem-dialkyl-7-oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasospastic disease have the structural formula wherein m is 1, 2 or 3; n is 0, 1, 2, 3 or 4;, Z is -(CH2)2-, -CH=CH- or with the proviso when Z is -CH=CH-, n is l, 2, 3 or 4; R is CO2H, CO2lower alkyl, or CO2alkali metal, X is O or NH; and where R1 and R2 are as defined herein and R3 and R4 are each independently alkyl, or R3 and R4 may be taken together with the carbon to which it is attached to form a 3- or 4-membered ring.
