183894-33-9

Upstream product

• 160238-45-9 (2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol 
• 212051-35-9 (R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 

Downstream Products

• 790662-54-3 (S)-2-[3-(4-methoxybenzyloxy)-2-methylpropyl][1,3]dithiane 
• 220018-29-1 (2R)-methoxy-4-[2-methyl-3-(phenylsulfonyl)propoxymethyl]benzene 
• 944943-11-7 (3R,4R,6S)-7-(4-methoxyphenoxy)-3,6-dimethyl-3,4-bis[(triethylsilyl)oxy]heptan-1-ol 
• 944942-96-5 (3R,4S,6S)-7-(4-methoxyphenoxy)-3,6-dimethyl-3,4-bis[(triethylsilyl)oxy]heptan-1-ol 
• 1030607-33-0 tert-butyl((1R,5R,6S)-5-((S)-5-(4-methoxybenzyloxy)-4-methylpent-1-en-2-yl)-2,6-dimethylcyclohex-2-enyloxy)diphenylsilane 
• 765915-17-1 (2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentan-1-ol 
• 1549648-60-3 C₃₆H₅₀O₅Si 
• 1549648-57-8 C₃₃H₄₆O₅Si 
• 1541193-50-3 (2S,4S)-5-(4-methoxybenzyloxy)-2,4-dimethylpentane-1,2-diol 
• 1541193-48-9 (2S,4R)-5-(4-methoxybenzyloxy)-2,4-dimethylpentane-1,2-diol 
• 1541193-41-2 (S)-1-(((2,4-dimethylpent-4-en-1-yl)oxy)methyl)-4-methoxybenzene 
• 790662-67-8 (2S,3R,5R,1'R,2''S)-2-[1'-(tert-butyldimethylsilanyloxy)-3'-(triethylsilanyl)prop-2'-ynyl]-3-(dimethylphenylsilanyl)-5-{2-[3''-(4-methoxybenzyloxy)-2''-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran 
• 790662-56-5 (2S,3R,5R,2'S,1''R)-1''-{(3-(dimethylphenylsilanyl)-5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)}prop-2''-yn-1''-ol 
• 790662-57-6 (2S,3R,5R,2'S,1''R)-1''-(3-(hydroxydimethylsilanyl)-5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol 

Relevant academic research and scientific papers

Formal synthesis of dictyostatin and synthesis of two dictyostatin analogues

A formal convergent synthesis of dictyostatin from (R)-Roche ester is described. Synthetic highlights include a Ni-catalyzed Nozaki-Hiyama-Kishi coupling between an aldehyde and a Z vinyl iodide to assemble the two main fragments, a diastereoselective Myers alkylation, a stereoselective Evans aldolization, two asymmetric Duthaler crotyltitanations, and a stereoselective Pd-catalyzed Marshall allenylindium addition to install the stereogenic centers of dictyostatin. The synthesis of (9R)-epi-dictyostatin and a new ring-contracted dictyostatin isomer were also achieved. Copyright

Synthesis of the C1-C12 acid fragment of amphidinolide T marine macrolides via SmI2-mediated enantioselective reductive coupling of aldehydes with a chiral crotonate

A new strategy for enantioselective assembly of the trisubstituted tetrahydrofuran ring has been established for synthesis of the C1-C12 acid fragment of amphidinolide T series marine macrolides. The key steps involve the SmI2-mediated highly e

Conformational analysis of axially substituted 4,4′-bi-1,3-dioxanyls

In contrast to the simple 4,4′-bi-1,3-dioxanyl derivative 6, which has no conformational preference at the inter-ring bond, the derivatives 9 and 10, which have two strategically placed axial methyl groups, show conformational preferences exceeding 95 %.

Synthesis of a Diels-Alder precursor for the Elisabethin A skeleton

A synthesis of a precursor 2 for the Elisabethin A skeleton is reported. Containing a masked quinone and a (E,Z)-diene sub-unit, it has the required elements for the envisaged intramolecular Diels-Alder reaction to form the tricyclic system of Elisabethin A. Starting from methylresorcinol, the sequence involves the preparation of an arylacetic acid, which was α-alkylated by a chiral building block. Subsequent HWE reaction and cis-selective Wittig olefination furnished the diene with the desired geometry.