1839-15-2Relevant articles and documents
Stable isotope13 Method for synthesizing C-labeled dichloroacetic acid (by machine translation)
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Paragraph 0022; 0027-0029; 0031-0033, (2020/08/26)
Stable isotope13 A method for synthesizing C-labeled dichloroacetic acid, comprising the following steps: (1). 13 C-labeled acetic acid is used as a raw material, and thionyl chloride and chlorine are added for reaction to obtain the intermediate13 C-labeled monochloroacetic acid; (2) The intermediate obtained in step (1)13 The C-labeled monochloroacetic acid is added with sulfur and chlorine to carry out cyclic reaction, and the obtained reaction liquid is adjusted to pH value by saturated sodium carbonate, and the equimolar amount of sodium thiosulfate is added for reaction and intermediate. 13 C mark a chloroacetic acid reaction, the reaction liquid is extracted with ethyl acetate to remove organic impurities, the aqueous phase is added with concentrated hydrochloric acid to pH value, extraction is carried out again with ethyl acetate, and the organic phase is dried. 13 C-Dichloroacetic acid. The present invention is a stable isotope. 13 C-labeled dichloroacetic acid provides a synthetic method which is mild in condition, easy to control and easy to operate, and is also suitable for radioisotopes. 14 Of C-Dichloroacetic Acid. (by machine translation)