1839619-50-9

Basic information

• Product Name: EnzalutaMide IMpurity
• Synonyms: EnzalutaMide IMpurity;Enzalutamide IMP;4-(3-(4-amino-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile;N,N'-bis[4-cyano-3-(trifluoromethyl)phenyl]-Thiourea
• CAS NO: 1839619-50-9
• Molecular Formula: C17H8F6N4S
• Molecular Weight: 414.33
• Mol File: 1839619-50-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 483.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.54±0.1 g/cm3(Predicted)
• PKA: 10.57±0.70(Predicted)
• CAS DataBase Reference: EnzalutaMide IMpurity(CAS DataBase Reference)
• NIST Chemistry Reference: EnzalutaMide IMpurity(1839619-50-9)
• EPA Substance Registry System: EnzalutaMide IMpurity(1839619-50-9)

Safety Data

• Hazardous Substances Data: 1839619-50-9(Hazardous Substances Data)

Usage

Uses

N,N''-Bis[3-(trifluoromethyl-4-cyanophenyl)thiourea can be obtained from 5-Amino-2-cyanobenzotrifluoride (A603630) which is used for the preparation of benzene derivatives as non-steroidal androgen receptor modulators.

Upstream product

• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 143782-23-4 4-isothiocyanato 2-(trifluoromethyl)benzonitrile 

Relevant articles and documents

Intermediate compound of enzaulatmide and preparation method of intermediate compound

The invention provides an intermediate compound of two kinds of enzaulatmide and a preparation method of the intermediate compound. Intermediates in a reaction process are researched, raw materials are skillfully selected, the intermediate compound can be discovered and prepared in a process of synthesizing the enzaulatmide by simply adding an organic solvent and water, and an important foundation is laid for further research of the enzaulatmide. When the intermediate compound of the enzaulatmide is synthesized, a preparation process is simple, the cost is low, and the yield and the purity are quite excellent.