183988-42-3

Basic information

• Product Name: N-(2,4-Difluoro-phenyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-acetamide
• Synonyms: N-(2,4-Difluoro-phenyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-acetamide
• CAS NO: 183988-42-3
• Molecular Weight: 321.348
• Mol File: 183988-42-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2,4-Difluoro-phenyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-Difluoro-phenyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-acetamide(183988-42-3)
• EPA Substance Registry System: N-(2,4-Difluoro-phenyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-acetamide(183988-42-3)

Safety Data

• Hazardous Substances Data: 183988-42-3(Hazardous Substances Data)

Upstream product

• 2462-02-4 2-mercaptoacetophenone 
• 96980-65-3 2-chloro-N-(2,4-difluorophenyl)acetamide 
• 532-27-4 1-chloroacetophenone 
• 367-25-9 2,4-difluorophenylamine 
• 53392-49-7 phenacyl thioacetate 

Relevant articles and documents

ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes

Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesteror esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds.