184042-10-2

Basic information

• Product Name: Benzenesulfonamide, 4-bromo-N-(3-methyl-5-isoxazolyl)-
• CAS NO: 184042-10-2
• Molecular Formula: C10H9BrN2O3S
• Molecular Weight: 317.163
• Mol File: 184042-10-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-bromo-N-(3-methyl-5-isoxazolyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-bromo-N-(3-methyl-5-isoxazolyl)-(184042-10-2)
• EPA Substance Registry System: Benzenesulfonamide, 4-bromo-N-(3-methyl-5-isoxazolyl)-(184042-10-2)

Safety Data

• Hazardous Substances Data: 184042-10-2(Hazardous Substances Data)

Upstream product

• 14678-02-5 5-amino-3-methylisoxazole 
• 98-58-8 4-bromobenzenesulfonyl chloride 

Downstream Products

• 184042-12-4 N-(3-methyl-5-isoxazolyl)-4-(3-methoxyphenyl)benzenesulfonamide 
• 184042-17-9 N-(3-methyl-5-isoxazolyl)-4-(3,4-methylenedioxyphenyl)benzenesulfonamide 

Relevant articles and documents

Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

Biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, bicyclic or tricyclic carbon or heterocyclic ring biphenylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

The discovery and structure - Activity relationships of nonpeptide, low molecular weight antagonists selective for the endothelin ET(B) receptor

The systematic modification of the ET(A) selective N-(5-isoxazolyl)benzene-sulfonamide endothelin antagonists to give ET(B) selective antagonists is reported. The reversal in selectivity was brought about by substitution of the 4-position with aryl and substituted aryl groups. Of all the aromatic substituents studied, the para-tolyl group gave rise to the most active and selective ET(B) antagonist. Larger substituents caused a decrease in both ET(B) activity and selectivity. A similar trend was observed by substitution at the 5-position of the N-(5-isoxazolyl)-2-thiophenesulfonamide ET(A) receptor antagonists. The para-tolyl group was again found to be optimal for the ET(B) activity and selectivity. The structural features that were found to be favorable for binding to the ET(B) receptor, that is, the presence of a linear, conjugated π-system of definite shape and size, have been successfully incorporated into the design of ET(B) selective polycyclic aromatic sulfonamides antagonists. Copyright (C) 1998 Elsevier Science Ltd.