184044-74-4Relevant academic research and scientific papers
A CYCLOADDITIVE ROUTE TO ENANTIOMERICALLY PURE 6-FLUOROMETHYL FUROISOXAZOLIDININES
Bandiera, Paola,Bravo, Pierfrancesco,Bruche, Luca,Zanda, Matteo,Arnone, Alberto
, p. 773 - 776 (2007/10/03)
A synthetic sequence to the title compounds is described, starting from the chiral and optically pure β-keto sulphoxide 1.The protocol involves Pummerer rearrangement of β-allyloxy sulphoxides 3 to the aldehydes 5, which are transformed in situ into the transient nitrones 6: these provide directly the bicyclic compounds 7, through a fully regio- and diastereo-selective intramolecular 1,3-dipolar cycloaddition.
